Endocrine Abstracts

Introduction: Type 2 deiodinase (D2) catalyses intracellular T3 production in several human tissues including pituitary gland, hence occupying an important role in the feedback regulation of TSH secretion. Although several previous researches have shown that Thr92Ala D2 polymorphism with decreased D2 enzymatic activity influences the levothyroxine dose requirement and the set point of the hypothalamus–pituitary–thyroid axis for postoperative TSH suppressiv...